Stimulation of Mitochondrial Activity by p43 Overexpression Induces Human Dermal Fibroblast Transformation

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Stimulation of mitochondrial activity by p43 overexpression induces human dermal fibroblast transformation.

Mitochondrial dysfunctions are frequently reported in cancer cells, but their direct involvement in tumorigenesis remains unclear. To understand this relation, we stimulated mitochondrial activity by overexpression of the mitochondrial triiodothyronine receptor (p43) in human dermal fibroblasts. In all clones, this stimulation induced morphologic changes and cell fusion in myotube-like structur...

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ژورنال

عنوان ژورنال: Cancer Research

سال: 2005

ISSN: 0008-5472,1538-7445

DOI: 10.1158/0008-5472.can-04-3652